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Tolerance varies, so adjust based on your own experience

Ghannoum M, Laliberte M, Nolin TD, Mactier R, Lavergne V, Hoffman RS, Gosselin S

Dec 22nd, 2025 The Science Behind Bioidentical Hormones Bioidentical hormones are plant-derived and structurally identical to your bodys natural hormones, offering a personalized option for restoring balance and relieving symptoms related to hormonal decline

Variants in FTO (fat-mass and obesity-associated), GLP1R (the GLP-1 receptor gene semaglutide's direct target), MC4R (a satiety-linked melanocortin receptor), and TCF7L2 (a glucose-homeostasis transcription factor) map your baseline metabolic terrain

The study, published in JAMA , found these adverse gastrointestinal effects happen in non-diabetic patients using the drugs specifically for weight loss

For this reason, its often favored for long-term anti-aging or metabolic wellness programs