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Adrenal insufficiency in mitochondrial disease: a rare case of GFER-related mitochondrial encephalomyopathy and review of the literature

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Gawrieh S, Dasarathy S, Tu W, Kamath PS, Chalasani NP, McClain CJ, et al

To confirm the phenotype changes were driven by OGDHc inhibition, we also treated cells with DM-2OG, mimicking impaired 2-OG metabolism by the OGDHc, and found that, similarly to ML226, DM-2OG increased the CCR7 high CD45RO high population, with a corresponding decrease in the CCR7 low CD45RO high population (Fig