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Conversely, inhibition of the PI3K/AKT/mTOR signaling axis sensitizes cancer cells to ferroptosis induction (111)

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e , Schematic showing how the iron-sulfur cluster-containing protein LIAS enables OGDH and PDH activity by transferring lipoic acid as a cofactor to their enzyme complexes (left)

Over the last decade, novel cell death pathways were discovered, including necroptosis, ferroptosis, cuproptosis, etc