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Individuals who may warrant closer monitoring include: Those with a personal or family history of depression , anxiety, or other mood disorders People who have previously experienced mood changes on other weight-loss medications or GLP-1-based therapies Individuals with eating disorders or a complex relationship with food , for whom appetite suppression may have psychological implications (see NICE guideline NG69: Eating disorders: recognition and treatment) [10] Those experiencing significant life stressors alongside starting a new treatment People with poorly controlled type 2 diabetes , where fluctuating blood glucose levels both hypoglycaemia and hyperglycaemia can independently affect mood, concentration, and emotional wellbeing It is also worth acknowledging that obesity itself is associated with higher rates of depression and anxiety, and that the psychological experience of rapid body weight change whether positive or negative can be emotionally complex

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Redefining GLP-1 Weight Loss Success Every members weight loss journey is highly complex and personal

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Higher investigational doses (25mg and 50mg) in the PIONEER PLUS trial showed weight reductions of approximately 10% body weight, approaching levels seen with injectable weight-loss medications

That's why GLP-1 therapy has moved well beyond diabetes care and into long-term metabolic medicine