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However, combining GLP-1 to estrogen delivers additional efficacy relative to GLP-1 alone on insulin sensitivity and glucose homeostasis in non-diabetic mice

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(PubMed) Nikiforov A, Kulikova V, Ziegler M

The rapidly increasing incidence and prevalence of diabetic patients and healthcare expenditure in Europe are indications of the increasing usage of diabetic drug products

Phase 2 trial data (NEJM, 2023) reported a mean body weight reduction of approximately 24% over 48 weeks at the highest dose, though larger Phase 3 trials are needed to confirm these findings