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The bioavailability difference only matters for oral, nasal, and topical routes of administration

Based on current available data for mass market dietary supplements

Baseline: 2 to 3 litres daily Training days: Closer to 3.7 litres, depending on your activity level First thing in the morning: About 500ml within 30 minutes of waking up That morning, your body loses fluid overnight, and GLP-1 medication can make morning nausea worse on an empty, dehydrated stomach

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