GLP-1R agonists (e.g., exendin-4 and liraglutide) reduce APP expression and processing in the brains of AD model mice through the activation of GLP-1R, decrease A protein production and plaque aggregation, and thus improve their spatial memory capacity (McClean et al., 2015
Funding The study was supported by Health and Medical Research Fund (project number 16172921)
This year, however, more than 1,025 people have so far lost their lives in drug-related violence which has already exceeded last years total of 910 victims
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However, GLP-1RAs have only been shown to reduce albuminuria, and their ability to reduce progression to ESRD remains to be elucidated