Ethnicity also plays a large role in the frequency of functional polymorphisms in pharmacogenes, and the appearance of these pharmacogenes can vary greatly between different ethnic populations (Suarez-Kurtz et al., 2014)
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Dysregulation of the endothelial cellular response to oxidative stress in cancer
As a result of the suppressed levels of catalase, there is an increased concentration of hydrogen peroxide, which can be further decomposed to hydroxyl radicals by a photochemical reaction (Schallreuter et al
GRN 498)
For patients who discontinued treatment during the study period, we used the day of treatment discontinuation (defined as the estimated end date of the most recent prescription plus the grace period of 90 days) as the start of follow-up to assess treatment reinitiation, defined as the first new prescription of the drug class that had previously been discontinued
