chills on tirzepatide 🧠Let's break the drug down using this mnemonic cloud!⁠ ⁠ 💉 Tirzepatide is a GLP-1 and GIP agonist. ⁠ ⁠ 🤔But what exactly is glucagon-like peptide (GLP-1) and gastric inhibitory polypeptide (GIP)? ⁠ ⁠ Issue with Tirzepatide : r/glp1

Such hyper-inflammatory state could lead to loss of appetite, altered intestinal absorption, impaired gut permeability, and malnutrition 683,684

Gut 63:727735 Burton JH, Johnson M, Johnson J, Hsia DS, Greenway FL, Heiman ML (2015) Addition of a gastrointestinal microbiome modulator to metformin improves metformin tolerance and fasting glucose levels

Satiation refers to the process occurring during a meal event that prompts eating termination and is associated with meal size, while satiety refers to the process occurring after a meal event, inhibiting further eating until the next meal [30,31]

Moreover, CICR requires continual activation of VDCCs by Ca 2+ within intracellular microdomains, but not by robust Ca 2+ influx from extracellular spaces [8,15,17,24]

however a weekly injection reduces the daily burden and removes strict timing constraints like no fasting requirement and wait for 30 min after dose

Weight-loss drugs were said to be a game changer