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Group 1 samples were transported to the laboratory in phosphate-buffered saline (PBS) (Gibco, New York, USA) on ice for cell isolation

Weight often returns after stopping the medication, indicating the need for ongoing lifestyle support, including healthy eating and physical activity

Fatigue: A temporary dip in energy as the body redirects resources toward cellular repair and detoxification

PPG NTS neurons are thus the crucial component of the central GLP-1 system, which they comprise along with numerous populations of GLP-1 receptor (GLP-1R)-expressing neurons found throughout the brain 11,12

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As a risk factor for various chronic diseases, the detection of TMAO and related metabolites can provide a potential basis for the prevention, diagnosis, and treatment of cardiovascular diseases, kidney diseases, neurological diseases, and metabolic diseases