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Mean percentage weight change shows the average group effect

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By contrast, the long-acting GLP-1RAs (semaglutide [ t 1/2 of 5 days] administered subcutaneously once-weekly or as a once-daily oral formulation and dulaglutide [ t 1/2 of 7 days] administered subcutaneously once-weekly) causing continuous exposure and activation of the GLP-1 receptor resulting in short-lasting effects on upper gastrointestinal motility (31) superseded by subsequent development of tachyphylaxis (16)