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Once off the medication, appetite typically returns to baseline within days to weeks, and weight regain commonly follows

If you have heart failure, it may get worse while you take TZDs with SEMGLEE

"This is a chronic disease that needs to be treated forever," says Apovian

Morning injections often help control appetite and blood sugar during the day, while evening doses may improve fasting glucose and reduce daytime side effects

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Those safeguards are part of the dosing plan