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These end-states were used to interpret the extreme ranges of heterogeneity present in the particle stack

They are not FDA-approved for treating diabetes or obesity and are not substitutes for prescription medications or evidence-based lifestyle interventions for metabolic health

Changes in apoptotic pathways (e.g., Bcl-2 protein family mutations), such as the overexpression of anti-apoptotic proteins, can prevent apoptosis and provide resistance to chemotherapy (54, 55)

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