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Remarkably, addition of GCGR co-agonism to GLP-1/GIP increased EE in obese mice 20,21 and in a phase 2 trial showed improvements in weight loss of 15% in 60%, 75% and 83% adults with obesity receiving 4, 8 and 12 mg, respectively 22

Currently, several long-acting dual GLP-1R/GCGR agonists are in various stages of clinical development

This is particularly beneficial for individuals dealing with blotchy or uneven skin due to sun damage or other factors

and as pharmaceutical supplements for individuals with nutritional deficiencies (Rebouche 1992)