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More important than net weight loss are changes in body compositionspecifically, reducing body fat while minimizing the loss of lean muscle mass
32 Similarly, a study carried out in the United Kingdom showed a discontinuation rate of 45% and 65% at 12 and 24 months, respectively
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It amplifies gastrointestinal side effects without a proven increase in benefit, and no clinical trial has studied the combination
Weight-loss outcome assumptions (15% average reduction in body weight over 12 months) were based on results from the STEP 1 and SURMOUNT 1 clinical trials
Compounded Drug Products That Are Essentially Copies of a Commercially Available Drug Product Under Section 503A of the Federal food, Drug, and Coametic Act: Guidance for Industry
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