The SUSTAIN and STEP trial programs for semaglutide, involving thousands of participants followed for up to two years, did not demonstrate an increased overall cancer risk compared to placebo groups
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These symptoms are typically mild and tend to dissipate over time
Huffman C, Stacey BR, Tuchman M, Burbridge C, Li C, Parsons B, et al
The article explains that these medications work partly by resetting appetite centers in the brain, so when the drug is withdrawn suddenly, appetite hormones and metabolic signaling return to their baseline patterns and can trigger compensatory overeating
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