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There was a low incidence of vomiting (8 events in 4 subjects [9% of subjects] all mild or moderate) and the duration did not follow an obvious pattern

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PMID: 23845922

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Exposure to amitriptyline induces persistent gut damages and dysbiosis of the gut microbiota in zebrafish (Danio rerio)

Notably, the diversification of gut microbiota resulting from metformin treatment was observed following oral administration in mice, a phenomenon not replicated with intraperitoneal injection (Wu H