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Synergistic Weight Loss A 2024 retrospective cohort study published in the International Journal of Obesity investigated the effects of combining a GLP-1 analog with a bupropion/naltrexone treatment

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doi:10.1016/S0140-6736(21)00213-0

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The cumulative incidence of first GI events plateaued after about week 20, indicating most participants experienced events during the dose-escalation period rather than at maintenance dose.[2] Bloating, abdominal distension, eructation (burping), and flatulence are part of the same family of effects

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Semaglutide-induced weight loss was primarily driven by loss of fat mass with a smaller contribution of fat free mass regardless of temperature ( Figure 1F-I )

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