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Conversely, synovial-derived cytokines such as IL-1 and TNF- further stimulate chondrocytes, aggravating lipid peroxidation and ferroptosis (140, 141)

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However, semaglutide-mediated potentiation of insulin secretion was only detected ex vivo , and does not explain circulating insulin levels in response to an oral glucose tolerance test (Figure 1D-E)

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