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It means they want more definitive long-term data, McGowan said

27 But human brain studies show a more widespread distribution in the cortex and striatum, with relatively less in brainstem nuclei

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This huge adherence gap means that real-world effectiveness falls far short of trial efficacy

In clinical trials, they helped people shed between 15% and 22% of their body weight -- up to 50 pounds or more in many cases

They are not to be used for personal ingestion, medical treatment, or any application outside properly authorized laboratory research.