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Shoemaker's research demonstrated that patients with CIRS consistently show severe abnormalities in inflammatory blood markers, including highly elevated TGF-beta1, C4a, and MMP-9, alongside drastically depleted levels of Melanocyte Stimulating Hormone (MSH) and Vasoactive Intestinal Polypeptide (VIP)

But as Joe Beer explains, new evidence suggests that we may have been too quick to dismiss its ergogenic properties

Tirzepatide came off the FDAs official drug shortage list in December 2024, and semaglutide followed in February 2025, eliminating the legal pathway that allowed compounding pharmacies to produce copies of the drugs

if secondary antioxidant reserves become saturated, or decline, and primary antioxidant defences are compromised, oxidative stress can become excessive

If you start off with low doses and inject just before you go to sleep you wont feel any side effects

Crump, R