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In an inflammatory state, knockout of Clec16a in cells can significantly increase apoptosis and sharply increase blood glucose levels in patients, and hyperglycemia further affects mitochondrial quality control, promotes cell damage, and exacerbates diabetes

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The condition is frequently associated with the presence of autoantibodies directed towards stomach cells (see Pernicious anemia) and/or infection by the bacteria, Helicobacter pylori ( H

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