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Choi, S

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BioMed Research International, 2014

Replicative endothelial cell senescence may lead to endothelial dysfunction by increasing the BH2/BH4 ratio induced by oxidative stress, reducing BH4 availability, and decreasing the expression of eNOS

Therefore, the same NO-therapy effect might indicate a particular match between the similar negative-like symptoms and the similar positive-like symptoms and shared NO-pathology [205,206,207,208,209,210,211,212,213,214,215]