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Additionally, in response to oxidative stress, PGC-1 orchestrates a complex reactive oxygen species (ROS) defense system vital for maintaining redox homeostasis

20 years of research and clinical studies support the efficacy of L.fermentum ME-3 for cardiovascular and metabolic disease prevention (reduction of oxidized LDL, cholesterol and triglycerides), anti-aging (systemic antioxidant effect), detoxification (liver function support)

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Montelukast attenuates interleukin IL-1-induced oxidative stress and apoptosis in chondrocytes by inhibiting CYSLTR1 (Cysteinyl Leukotriene Receptor 1) and activating KLF2 (Kruppel like Factor 2)

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The BDNF upregulation has been documented in both animal and human studies, providing a plausible and measurable mechanism