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Unlike the potent TGR5 agonists, DCA and LCA, we could not detect any effects of TMCA on cAMP levels in the STC-1 cells, NCI-H716 cells, and mouse intestinal organoids, suggesting that the increased ileal TMCA observed in the mice after T3 treatment might not act via TGR5-mediated pathway

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This can indicate microbial contamination or peptide degradation

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This reaction is catalyzed by the enzyme methionine synthase with B 12 as an essential cofactor

UHIC has faced significant increases to administrative expenses, driven by inflationary pressures