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While the timing of semaglutide administration does not fundamentally alter the medication's side effect profile, strategic timing may help some patients better manage gastrointestinal symptoms, which are the most commonly reported adverse effects

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Specifically, we dissect how baseline microbial signatures correlate with differential efficacy, while critically assessing clinical confounding factors, such as metformin co-treatment and dietary shifts, and the methodological limitations that currently hinder the translation of microbiome profiling into precision endocrinology

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& Khalili, K

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