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Common side effects of semaglutide include nausea, vomiting, and diarrhea as the body adjusts to the medication

doi: 10.3389/fphar.2025.1483548 Received 20 August 2024 Accepted 07 January 2025 Published 05 February 2025 Volume 16 - 2025 Edited by Luca Rastrelli, University of Salerno, Italy Reviewed by Ricardo Albuquerque, National University of Trujillo, Peru Minhajur Rahman, University of Chittagong, Bangladesh Tuoyi Wang, Qiqihar University, China Updates Copyright 2025 Anjum, Nasir, Naseer, Ibrahim, Rehman, Bashir and Tul Ain

This surprisingly long research timeline matters because it shows how GLP-1 science has matured

doi: 10.1152/ajprenal.1995.269.2.F225

In people living with obesity, this natural GLP-1 signaling system is often impaired or insufficient the brain does not receive proper satiety signals, appetite remains elevated, and the metabolic processes that regulate fat storage become dysregulated

Most clients report it feels like a brief pinch, and then it's over