Nakamura T, Tanimoto H, Okamoto M, Takeuchi M, Tsubamoto Y, Noda H
3.4 Glucoselipid metabolism and IR Insulin resistance serves as the crucial hub connecting metabolic derangements and reproductive dysfunction in PCOS, making it a primary target for GLP-1RA intervention within the metabolicreproductive axis
He has previously received research support from Microsoft, Alphabet, Intel, IBM and Bayer
Small-molecule oral GLP-1 RAs, such as orforglipron and danuglipron, are in development or early clinical trials
GLP-1s also stimulate insulin release, so with less glucagon and more insulin, your body uses glucose better
Importantly, GLP-1 appears to attenuate reward-driven food consumption by modulating dopaminergic signaling in the mesolimbic system, potentially reducing preference for high-fat, energy-dense foods [36]