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Thalamic reticular nucleus impairments and abnormal prefrontal control of dopamine system in a developmental model of schizophrenria: prevention by N-acetylcysteine

PEPITEM-derived tripeptides showed results in as little as 7 days in preclinical studies

The downregulation of acylcarnitines, which are involved in intracellular fatty acid oxidation, suggests impaired fatty acid oxidation and mitochondrial dysfunction

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In summary, ferroptosis is a key regulator of lipid metabolism, with its dysregulation contributing significantly to NAFLD progression

It was initially established in mice and applied as a proof of concept in two CPVT patients [28], but has since then become a class IIa guideline recommendation [29]