The result is a peptide that retains structural integrity in environments, gastric fluid, intestinal lumen, serum, where conventional peptides are inactivated within minutes
728 This process is regulated by AMPK, which promotes FAO by inhibiting the phosphorylation of ACC, 729 thereby maintaining a balance between NADPH consumption in fatty acid synthesis and NADPH production via FAO
This process promotes effective infiltration of immune cells such as CD8 + T cells and NK cells and facilitates the formation of immunological memory, thereby exerting anti-tumor effects [295, 303, 304]
3.2 Non-enzymatic mechanisms 3.2.1 Disorders of iron ion metabolism As mentioned previously, ferroptosis is primarily triggered by iron-dependent lipid peroxidation
The metabolite BH4 controls T cell proliferation in autoimmunity and cancer
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