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Patients should be counselled about common gastrointestinal symptoms, advised to start with the lowest dose (2.5 mg weekly), and informed that side effects typically improve over 4-8 weeks as tolerance develops

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In 2005, more than 15 years later, the first GLP-1 drug for diabetes was approved

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Titration Schedules Many GLP-1 agonists require a gradual dose escalation, known as titration, to help minimize gastrointestinal side effects like nausea and vomiting