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During the development of nonalcoholic fatty liver disease (NAFLD), disorders of the carnitine pool are considered important drivers, in which the LCAC profile changes significantly with the progression of NAFLD and provides key clues for revealing the complex pathogenesis of NAFLD [209, 210]
& Baek, J
Lgr5(+) pericentral hepatocytes are self-maintained in normal liver regeneration and susceptible to hepatocarcinogenesis
These proteins form what is called an apoptotic blockade, meaning that cells cannot undergo apoptosis, even when they experience DNA damage that would normally trigger cell death
PMID: 31281577
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