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Additionally, GLP-1 RAs exhibit neuroprotective and anti-inflammatory effects, increase Akt dephosphorylation, decrease proinflammatory factors such as TNF-, elevate neurotrophic factors like BDNF, reduce oxidative stress and microglial activation, and enhance gut-brain axis function and gut microbiota stability [176]

Marazzato F, McCarthy C, Field RH, Nguyen H, Nguyen T, Shepherd JA, et al

It is essential to emphasize that tirzepatide does not replace thyroid hormone replacement therapy, does not reduce thyroid antibody levels, and does not modify the autoimmune process in Hashimoto's disease

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The cardiovascular data has been encouraging, and in the right patients, theyre usually well tolerated and can really help make a difference when combined with lifestyle changes