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In both humans and animal models, microglial activity correlates with neuronal death, starting prior to the death of dopaminergic neurons and exerting a neurotoxic effect on dopaminergic neurons that can result in neurodegeneration (Gao et al., 2002

Khoraminya N, Tehrani-Doost M, Jazayeri S, Hosseini A, Djazayery A

Many systemic inflammatory conditions have gastrointestinal components that benefit from this approach