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Moreover, the use of analgesic medications, such as opioids, can exacerbate this dysbiosis, damage the intestinal epithelial barrier function and promote the translocation of gut microbiota, which increased susceptibility to PND (Mora et al., 2012

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Under these conditions, acetic acid becomes a crucial source of acetyl-CoA in tumor cells [46]

Lack of signaling pathways that can modulate ACD occurrence suggests that ACD cannot be targeted pharmaceutically [4]

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