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It's the professionally accepted timeframe during which the preservative can reliably maintain its bacteriostatic properties through multiple entries into the vial
When concentrations are in the range between four times and one fourth of the C 50 , the time course of effect is essentially a linear function of time
The animals were treated according to the european community prescriptions [EU (86/609/EEC)], then cycled and mated with fertile males at proestrous on 120 d of age, with a positive vaginal smear for sperm, the day after proestrous indicating d 0 of pregnancy
The abnormal architecture of the tumor vasculature results in hypoxia, immune exclusion, and poor drug delivery, thus promoting therapeutic resistance (128)
The dosage and frequency of administration are tailored to the patient's individual needs and should be determined by a healthcare professional