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Long-term biocompatibility issues arise from nanoparticles which trigger inflammatory responses together with oxidative stress and immune system activation in tissues that need no treatment [43]

doi:10.3389/fendo.2023.1215356

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The authors reported a 55.8% reduction in facial wrinkle volume and a 32.8% reduction in wrinkle depth compared with control serum, alongside in vitro evidence that GHK-Cu increased both collagen and elastin production in human dermal fibroblasts at concentrations as low as 0.01 nM [4]

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