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Roughly 85% to 90% of a therapeutic dose undergoes Phase II conjugation (glucuronidation via UGT1A1, UGT1A6, and UGT1A9, plus sulfation via SULT1A1), with only about 5% to 10% oxidized by CYP2E1 into the reactive metabolite NAPQI, per Hodgman and Garrard's pharmacology review

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It is modeled after Epithalamin, a peptide linked to the pineal gland, an area of the body connected to biological timing signals

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Oral semaglutide was generally well tolerated across the trial treatment period, although a greater proportion of participants experienced AEs leading to premature trial discontinuation with oral semaglutide than with sitagliptin