The disruption of mitochondrial membrane structure and function can attenuate the activity of these enzymes, resulting in oxidative stress-induced damage to the mitochondria [46]
Sci Transl Med 2013;5:209ra151.ArticlePubMed 26
His family history worried him, too, as diabetes and obesity run on his moms side and heart conditions on his fathers
The FDA Orange Book lists only three categories of patents for NDA-approved drug products: drug substance patents (covering the API), drug product patents (covering the finished formulation), and method-of-use patents (covering an approved indication)
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