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The insulin receptor is a large transmembrane glycoprotein consisting of two identical alpha-subunits and two identical beta-subunits connected by disulfide bridges

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Bazzano, G

Figure 1 GLP-1 RAs also gain access to hindbrain sites indirectly via the vagus nerve

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6,14 Furthermore, GLP-1 signaling indirectly enhances and restores the insulin signaling pathway in neurons, leading to a reduction in the phosphorylation of insulin receptor substrates and the burden caused by monomeric -synuclein