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Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration

Grapefruit contains approximately 13 nM of glutathione per gram

10.1016/j.cellsig.2017.01.004 242 XuY.MaH.ShaoJ.WuJ.ZhouL.ZhangZ.et al (2015)

Activation of GATA-1 by small molecules may decrease Kupffer cell number in the liver and improve hepatocyte engraftment

However, the actions of H 2 S are strictly concentration-dependent, acting as a double-edged sword: at physiological levels it functions as a beneficial signaling molecule, whereas at high concentrations it becomes strongly cytotoxic by inhibiting cytochrome c oxidase (Complex IV) at the end of the mitochondrial respiratory chain, leading to energy depletion (Caro et al., 2011

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