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(Peptide Sciences) While senescence is protective in acute contexts (e.g., preventing malignant transformation, wound repair), the accumulation of senescent cells over time is detrimental: They occupy tissue space and resources, impairing progenitor cell function

100 Analysis of The Cancer Genome Atlas data showed that low MPC1 expression in head and neck cancer (HNC) tissues was associated with poor overall survival

All research cited refers to preclinical and in vitro studies