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This proposed hierarchical framework requires validation through systematic metabolomic and functional studies to establish the relative contributions of different metabolites, thereby informing targeted therapeutic strategies (Figure 1)

Glutathione is sold as an herbal supplement and is available in oral capsules, topical creams, and injectable forms

Cycling further reduces any risk

In addition, we found that autophagy is activated in the process of ferroptosis and reduces SIPS, suggesting an essential role of autophagy in ferroptosis and SIPS

* Correspondence: Hongying Kuang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

however, due to the detoxification reaction, some patients may experience mild headaches or nausea.