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The compound was originally developed by Ipsen but was licensed to Rhythm Pharmaceuticals in 2010 ( Setmelanotide is a MC4R-selective disulfide-cyclized octapeptide that incorporates several noncanonical amino acids ( Figure 2 ) ( 50 = 0.27 nM) with reduced activity on hMC1R (EC 50 = 5.8 nM) and hMC3R (EC 50 = 5.8 nM) ( Table 1 ) ( 50 = 0.053 nM) and the hMC3R (EC 50 = 0.82 nM) ( Table 2 ) ( s pathway ( q , with superior potencies compared to -MSH and LY2112688

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Targeted thiol analysis Sample preparation Thiol concentrations within P

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