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6,20 Infants with G6PD deficiency and a mutation of uridine diphosphoglucuronate glucuronosyltransferase-1 gene promoter (UDPGT-1) are particularly susceptible to hyperbilirubinemia secondary to decreased liver clearance of bilirubin

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The peptide is found throughout the body and circulates at higher levels in younger tissue, with concentrations that tend to fall with age

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Experimental models of metabolic syndrome also show that, besides the regulation of MAPK, other transcriptional factors such as peroxisome proliferator-activated receptor gamma (PPAR), CAAT/enhancer binding protein- (C/EBP) and sterol regulatory element binding protein (SREBP)-1c are increasingly studied for their role in adipogenesis and lipid-induced hepatic toxicity [31,34,35]

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This process is central to cellular motility in experimental models as it directs the movement of cells during wound-closure assays

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