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however, the type, severity, and frequency of these effects may differ between agents, formulations, and dosing schedules

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Both approaches involve the attempt to remove malignant cells and spare normal tissues, though this remains difficult due to the heterogeneity of tumour s, intrinsic drug resistance and the ability of normal tissues to be affected adversely by anticancer treatments

Patients frequently experience: Fatigue and generalised weakness that persists despite adequate rest Breathlessness on exertion due to anaemia Palpitations and reduced exercise tolerance Pallor of the skin and mucous membranes These symptoms result from megaloblastic anaemia, where impaired DNA synthesis leads to the production of abnormally large, dysfunctional red blood cells with reduced oxygen-carrying capacity