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Vitamin D status is independently associated with insulin resistance in patients with type 2 diabetes mellitus

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Trp is metabolized to Kyn by tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase in the Kyn pathway, and to 5-HT by tryptophan hydrolase (TH) and aromatic amino acid decarboxylase (AAD) in the serotonin pathway (Fig