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each discovered a new tear fluid biomarker for AD, reporting elongation initiation factor 4E (eIF4E) 18 and adenylyl cyclase-associated protein 1 (CAP1) 19 , respectively

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DECLARATIONS Authors contributions Drafted the manuscript: Valds-Calero I Revised the manuscript critically for important intellectual content: Rodrguez A, Frhbeck G All authors participated in final approval of the version to be published

Yamamoto Y, Mochida J, Sakai D, Nakai T, Nishimura K, Kawada H, Hotta T: Upregulation of the viability of nucleus pulposus cells by bone marrow-derived stromal cells: significance of direct cell-to-cell contact in coculture system

Minimum assessment periods of four weeks, preferably eight, provide realistic timeframes for evaluating concentration changes

This non-toxic profile distinguishes it from many other biologically active compounds and supports its favorable safety record