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Abrar Qureshi

How to Switch The transition is straightforward: Stopping Saxenda: No taper required Can stop after last daily dose No withdrawal effects Starting semaglutide: Begin at starting dose (0.25mg weekly) Follow standard titration schedule Some providers start at higher doses for patients switching from other GLP-1s, but standard titration is safest Timing: Can start semaglutide the week after stopping Saxenda No mandatory washout period Some providers start immediately after last Saxenda dose What to Expect During transition: Appetite suppression may temporarily decrease during early semaglutide titration GI side effects may recur as you adjust to new medication Full semaglutide effect takes 4-5 months to reach After transition: Most patients see additional weight loss beyond what Saxenda achieved Weekly dosing is typically more convenient Similar ongoing management Transition Considerations Timing expectations: Dont expect immediate additional weight loss Titration period is necessary even for patients experienced with GLP-1s Full benefit of switch becomes apparent at maintenance doses Managing expectations: Some initial adjustment period is normal The convenience benefit is immediate Weight loss benefit develops over months Practical Considerations for Each Medication Understanding day-to-day use helps set expectations

This chemical is necessary because without it, the digestive system would destroy semaglutide before it could reach the bloodstream

doi: 10.1038/s41586-020-2456-9 231 Robledinos-AntnN.Fernndez-GinsR.MandaG.CuadradoA

Uroevi M, Nikoli L, Gaji I, Nikoli V, Dini A, Miljkovi V

Acknowledgements This research was funded by the Natural Science Foundation of Zhejiang Province (No