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Slower digestion means more time for gut bacteria to ferment food, which can produce gas, and more time for the colon to reabsorb water, which can make stool harder to pass

doi: 10.1080/08998280.2025.2456441

Adjustment strategies relied on measured confounders such as HbA1c and BMI but could not fully account for time-varying confounding by indication

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Studies in mice with CNS neuron-specific GLP-1R knockout showed that liraglutide failed to induce weight loss but still improved glucose levels, suggesting that brain GLP-1Rs are necessary for the weight-lowering effect of GLP-1RAs but not essential for their glucose-lowering effects (142)

Effects of semaglutide-loaded lipid nanocapsules on metabolic dysfunction-associated steatotic liver disease